How Immunocal Can Raise Glutathione GSH Level in Our Cells and Optimize The Immune System
The most essential antioxidant of all is not in a fruit, a vegetable, or a pill. It's already in your body! It is glutathione GSH. Immunocal is the only dietary supplement scientifically proven to consistently raise glutathione levels, therefore optimize the immune system which enhances energy levels and vitality for an improved quality of life.
¿Qué es glutathione /Immunocal? ---
En quoi consiste le glutathion /Immunocal? ---
Deutschland Deutch Was ist glutathions /Immunocal?
Dr. Jean Marcoux M.D - "Almost everyone I put on Immunocal tells me that they feel better as soon as they start taking the product. This is explained by the fact that Immunocal brings to all the cells in our body, the building blocks necessary to produce glutathione, a small protein that each cell needs to function properly. In severe asthmatics taking Immunocal, the attacks become less frequent and less severe. The need for medication is decreased, they sleep better, they don't miss work or school as often, resulting in a better quality of life." Dr. Jean Marcoux is a Board Certified Allergist, Immunologist Whey, glutathione Summary and Abstracts Studies
Robert O. Young D.Sc., Ph.D - "In the last ten years, over 25,000 medical articles about Immunocal have been published, and the scientific understanding of glutathione is gradually becoming common knowledge." Scientifically Studied: Immunocal is proven and patented to raise glutathione GSH level. It is a natural source of the glutathione building block called cysteine, that addresses several critical factors affecting your quality of life and for the maintenance of a strong immune system. Glutathione is the most prevalent, natural, powerful and multifunctional antioxidant in the human body and is employed by every organ. Health benefits from regular consumption of Immunocal by Wulf Droge, PhD The most frequent complaint by far is the difficulty of mixing the product. Immunocal could be put into capsules, but you would need to take about 30 to 60 capsules per day to get 10 to 20 grams of the product...which is not very practical. It cant be made into a liquid, as the shelf life would go from 2 years to a few months. It can’t be flavored, or have agents added to it (to improve mixing) as we have customers with multiple chemical sensitivities who could not tolerate any additives to the product. The videos just below demonstrate the best ways to prepare or mix Immunocal.
The proteins in Immunocal are very fragile. Do not heat this product or add it to hot liquids. Do not use a high-powered blender to mix. Heat and severe mechanical action will break down the protein and diminish the usefulness of the product. Immunocal is a dehydrated powder. It must be rehydrated with liquids before use. If left standing too long after mixing, the usefulness of the product may be reduced. It is generally recommended to consume the product within 30 minutes of mixing. Special low-speed blenders or mixing cups can be made available through Immunotec Inc.’s distribution networks.
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Q. What is Immunocal bioactive whey protein? What is HMS-90?
A. Immunocal is a specific brand of bioactive whey protein (which is also called Humanized Milk Serum, or HMS-90 in Canada). There are several other brands of bioactive whey proteins, but at the time of this writing, none of these brands are backed by clinical research. Immunocal is not a prescription drug, but a patented (8 Method of Use Patents world-wide, and 5 US Patents) un-denatured and bio-active whey protein dietary supplement that is rich in glutathione precursors.These US patents include: Biologically active whey protein concentrate, Biologically active undenatured whey protein, Undenatured whey protein concentrate to improve active systemic humoral immune response, Method of treatment of HIV-seropositive individuals with dietary whey proteins, Anti-cancer therapeutic compositions containing whey protein concentrate, and Use of a decapeptide with benzodiazepine-type activity for preparing medicines and food supplements
Immunotec invested over $10 million and 18 years of research into their product, which is extremely rare for a non-prescription nutritional supplement. The primary researcher involved in the discovery of Immunocal bioactive whey protein is Gustavo Bounous, MD. Immunocal bioactive whey protein is a highly concentrated milk serum isolate which is high in protein (90% protein by weight) and is lactose-free, carbohydrate and sugar-free, and fat-free. Immunocal shares many of the same immune promoting and enhancing properties of Mother's milk. Immunocal has been clinically proven to increase serum and tissue glutathione levels, and is validated by extensive research, including numerous published scientific studies and review articles which appear in the medical literature and are available for you to examine through our MEDLINE (National Library of medicine) link. Immunocal increases glutathione, which is your cells' own natural antioxidant and most potent detoxifier. Immunocal has been demonstrated to enhance both healthy and deficient immune systems, and is validated as an effective nutritional supplement by the medical community. Immunocal is the only non-prescription dietary supplement to appear in the year 2000 through 2008 Physician's Desk Reference (PDR) for Prescription Drugs, although it is available without prescription! It has it's own NDC (National Drug Control) number, and is reimbursable under Medicaid, Medicare, and by private insurance in many states. Top
Q. Is Immunocal bioactive whey protein approved by the FDA for the treatment of cancer, chronic fatigue, autoimmune, and glutathione deficiency diseases?
A. No. The United States Food and Drug Administration (FDA) does not "approve" any nutritional supplements for these indications. The FDA determines the safety of nutritional supplements, and regulates or restricts the distribution of those products considered to pose a health risk to the American public. Immunocal is considered to be "generally recognized as Safe", (GRAS) by the FDA. This is the same classification given vitamin C. Based on a recent decision by the US Court of Appeals for the District of Columbia Circuit, the FDA is tolerating references to certain therapeutic uses of nutritional supplements which are based on strong scientific or clinical evidence and "significant scientific agreement". Because Immunocal bioactive whey protein is manufactured by a Canadian company, the manufacturer is more sensitive to the regulatory pressures of the FDA than American supplement manufacturers, and has chosen to be ultra-conservative in their marketing of the product. Each box of the product is produced from 500 liters (125 gallons) of fresh, organic milk from free-range, grass-fed cattle on a contract farm in the state of Idaho. No disease treatment claims are made concerning bioactive whey protein. Top
Q. What is the difference between Immunocal bioactive whey protein and other whey proteins?
A. Immunocal bioactive whey protein has been shown to differ from other whey proteins in its effect upon the immune system. Specifically, scientific studies on other whey proteins have not shown the same immune stimulating effects that are seen with bioactive whey protein. Immunocal bioactive whey protein has been extensively studied in the clinical literature. Comparing Immunocal bioactive whey protein to other commercial whey proteins clearly shows the superiority of bioactive whey protein. Immunocal bioactive whey protein is one of 4 commercially available bioactive whey proteins, but it is the only one that is supported by eighteen years of research and by both animal research and human clinical trials. Bioactive whey protein studies (done with Immunocal) have shown that they not only increase intracellular levels of GSH (glutathione or glutathione precursors) following ingestion, but also significantly build up the stores of these substances inside the cells. This beneficial effect lasts for considerable periods of time after ingestion of bioactive whey protein. Top
Q. What is the product's bioactivity dependent upon?
A. Concentrations of 3 bioactive and thermolabile (easily damaged by heat) proteins that are contained in the milk serum: serum albumin, alpha lactalbumin and lactoferrin. Because these compounds can be damaged by heat (in excess of 140 degrees F) or excessive mechanical agitation, bioactive whey protein must not be cooked, heated, or placed in a steel-bladed blender. For these reasons, and to preserve the bioactivity of its serum albumin, alpha lactalbumin and lactoferrin, bioactive whey protein has not been exposed to standard high-temperature Pasteurization. Rather, it has been bio-filtered to remove bacteria, and subjected to patent-process low-temperature purification procedures to ensure its safety and purity. Top
Q. If a different manufacturer of whey protein supplements was able to duplicate Immunotec's technology, could they make the same claims?
A. No. The method of use patents preclude another manufacturer from duplicating the manufacturing process of Immunocal. Immunotec Immunocal bioactive whey protein patents (presently there are eight patents on bioactive whey protein: 5 US patents, and 3 international patents) relate to the METHOD OF USE. That is, no other whey protein can state: "clinically PROVEN to stimulate the immune system", and "significantly raises glutathione levels". Additionally, although there are dozens of companies producing denatured (high-heat Pasteurized) whey proteins (primarily for use as a protein source in body-building), there currently is no company manufacturing an UNDENATURED whey protein product similar to Immunocal bioactive whey protein. Numerous clinical studies and medical reviews appear in the clinical literature which specifically involved the Immunocal brand of bioactive whey protein, and not other high-heat pasteurized commercial whey proteins. Accept no imitations. Top
Q. What exactly is glutathione and how is it important?
A. Glutathione is the master antioxidant of the body. Without glutathione, we die. The replenishment of the glutathione levels within the lymphocytes (also called leucocytes or white blood cells) increases the intensity of the immune response. The increase in glutathione levels also results in the proliferation of lymphocytes that act as a scavengers, and helps to combat infections. Selenium (a micronutrient and mineral) is a structural component of, and a co-factor for the antioxidant enzyme glutathione peroxidase. For this reason, supplementation with selenium can modestly increase glutathione levels in persons who are selenium deficient. Glutathione is a tri-peptide of the amino acids cysteine, glycine, and glutamic acid. Tissue glutathione levels increase when cystine levels increase within the cell. This is why cystine is critical in the production of glutathione, but prior to the development of bioactive whey protein, no effective way was known to safely and significantly increase cystine levels in the cell over long periods of time. A deficiency of glutathione can cause hemolysis (the destruction of red blood cells resulting in severe anemia) and numerous diseases of oxidative stress. Low glutathione levels are commonly found among the elderly, those undergoing cancer chemotherapy, and among patients suffering from autoimmune and immune deficiency diseases such as rheumatoid arthritis, chronic fatigue syndrome (CFSIDS), fibromyalgia, and AIDS. Glutathione is essential in intermediary metabolism as a donor of sulfhydryl groups (which are essential for the detoxification of the liver). That is why the only known "side effects" associated with bioactive whey protein supplementation are associated with the beneficial detoxification which occurs as a result of improved liver function. The antioxidant enzyme glutathione peroxidase functions in the process of elimination of wastes from the body. Glutathione works within the liver, lungs, colon, kidneys, and skin in the process of removing toxic eliminating cellular metabolic wastes. Top
Q. What is the difference between products or pills that people use as supplements that are labeled as "glutathione" or "cystine"?
A. Glutathione is produced within the cells (intra-cellularly). When taking a pill labeled "glutathione", clinical and laboratory studies demonstrate that oral glutathione is NOT absorbed but will be eliminated by the liver through the bile before ever reaching the systemic circulation (blood stream). Cystine is not well absorbed when taken by mouth. Injectable glutathione also has limited benefits. It is unstable in the blood stream. By the time it gets to the cell, much of it gets degraded, and much of this remaining glutathione cannot effectively pass through the cell membrane.Clinical studies have demonstrated that oral cystine supplementation (NAC or N Acetyl L-Cysteine) is NOT effective in increasing cystine levels within the cell, and has also not been associated with significant increases in glutathione levels within the cell. The three bioactive proteins supplied by bioactive whey protein constitute a "natural delivery system" from these cystine precursors to the cell (in order to facilitate clinically and statistically significant increases in glutathione levels in BOTH the extracellular serum and intracellular tissues). Because Immunocal bioactive whey protein provides the building blocks for cystine, and these building blocks for cystine are easily transported inside the cell where they can be quickly synthesized into glutathione, bioactive whey protein is therefore ideally suited to increase glutathione levels within the cell. Top
Q. What is the difference between NAC (N Acetyl L-Cysteine) and bioactive whey protein?
A. N Acetyl L-Cysteine (NAC) is sulfur-containing (sulfhydryl) amino acid which is present in many proteins, and is in the same class as the amino acid methionine. NAC is a naturally occurring amino sugar and is a form of cysteine which has been demonstrated to facilitate the SHORT TERM cellular detoxification of alcohol, tobacco smoke, acetaminophen [Tylenol®] poisoning and environmental pollutants in several in vitro studies. When Cystine is heated, molecular bonds are cleaved and it becomes Cysteine. Cysteine is beneficial if it is produced INSIDE the cell, but is mildly toxic if it is produced outside the cell. NAC does not travel well in the blood stream, and doesn't reach the cells (to be used to synthesize glutathione and Glutamic acid). NAC supplementation over long periods has been associated with modest increases in serum glutathione, but has not proven particularly useful in the treatment of chronic, long-term intracellular glutathione deficiencies. Furthermore, therapeutic levels of NAC are relatively toxic and have been associated with significant side effects. At therapeutic doses, oral NAC supplementation has been associated with cerebral symptoms, nausea, blurred vision, and vomiting. Immunocal bioactive whey protein provides the precursors for the manufacture of intra-cellular cystine, and effectively delivers these to the cell. For this reason, bioactive whey protein supplementation has been associated with sustained and significant increases of cellular glutathione, and is virtually devoid of troublesome side-effects. Bioactive whey protein has the same side-effect profile as mothers' milk. Top
Q. What is the difference between bovine colostrum and bioactive whey protein?
A. The proteins in colostrum have almost no cystine content. Cystine is critically essential to the immune system. Although Growth Factors present in colostrum (including IGF-1, or Insulin-like growth Factor-1 which is effective in promoting muscle growth) are not affected by stomach acid, research published by one manufacturer of Colostrum (Vital Health News, Winter 1998, page 7) demonstrated that "the effectiveness of the immune factors present in colostrum is lowered by stomach acid." Although the immune enhancing factors found in colostrum are often "preferable to single isolated immune components" (such as interferon, which is more likely to cause troublesome side effects), colostrum has NOT been demonstrated to be superior to isolated undenatured whey proteins such as Immunocal bioactive whey protein. Colostrum (which is produced during the first 26 hours following birth by the mammary glands) is primarily composed of immunoglobulin and some lactoferrin. According to both laboratory experiments and clinical trials conducted in Germany, although colostrum supplementation was associated with mild increases in immune function in some patients, these increases were not statistically significant, (p=ns). A postulated mechanism of action of colostrum is the inter-species transfer of immune factors, however this has NOT been clinically proven. Most of the data supporting the effectiveness of colostrum is anecdotal (consisting mostly of personal testimonies rather than clinical studies). Since the primary mechanism of action on the immune system is via stimulation of the synthesis (production) of glutathione, the near absence of glutathione precursors in the immunoglobulin fraction (from the colostrum) may explain its relative lack of effect. Conversely, bioactive whey protein contains substantial amounts of thermolabile (heat-sensitive) proteins that are rich in cystine and glutamylcystine (known precursors of glutathione), and Immunocal bioactive whey protein has been validated in numerous human clinical trials which found statistically significant increases in glutathione and indices of immune function (such as CD4:CD8 ratios). Colostrum might be beneficial as an adjunctive (add-on) to bioactive whey protein, but the clinical data is significantly more convincing for bioactive whey protein. Top
Q. How does the manufacturing of Immunocal differ from other whey proteins?
A. In the manufacturing of other whey proteins several things occur: in the process of heating and Pasteurization, critical bonds holding the cystine together get broken down ("denatured", meaning they lose their original nature--similar to the denaturing and irreversible changing of liquid egg white by the heating process involved in frying an egg). The exact type of proteins that serve to increase tissue and serum glutathione most effectively are lost or diminished. Researchers have developed a process by which these delicate proteins remain intact in their natural form to serve us most effectively. Top
Q. Is Immunocal bioactive whey protein free from Bovine Growth Hormone, antibiotics, and other chemicals?
A. rBGH (bovine Growth Hormone) and other growth hormones have become a major issue of controversy in the dairy industry. Certain herdsmen give their cows the growth hormone to increase milk production. It is devastating to the cows, and to those who drink their milk also. American dairy farmers in the state of Idaho provide the milk to manufacture Immunocal bioactive whey protein from one large dairy farm in the state of Idaho. This particular location was chosen because the soil selenium levels are highest in the USA, and grazing on grasses which are grown on Idaho selenium-rich soil results in high selenium levels in the milk. Selenium (an essential micronutrient and mineral) is a structural component of the powerful "master antioxidant" glutathione. The selenium level in 10 grams of bioactive whey protein is more than 4 mcg, which is much higher than found in most commercial whey proteins. That is good. This facilitates the cystine component of the whey protein (bioactive whey protein is 100% whey protein) from this selenium-rich milk to be more effeciently metabolized by the body to form glutathione within the cells of the body. On the other hand, absolutely no herbicides, pesticides or chemicals are used on the grasses these cows graze upon. The milk from these cows qualifies to be certified organic (hormone, pesticide and agricultural chemical-free). The cattle on this farm are subjected to more rigorous standards than almost any other dairy cattle in the USA. If a cow is sick and must be treated with antibiotics (or any other pharmaceutical compound), it is removed from the herd and its milk is not used. Absolutely no BGH or other hormone compounds are used on these cows. Top
Q. What are some additional benefits of whey proteins?
A. Immunocal bioactive whey protein has been clinically demonstrated to increase exercise capacity by 13 percent (Lands et al., 1999), and may be useful as a supplement for competitive athletes. Wattanabe et al. (Japan) conducted a clinical study with bioactive whey protein to evaluate increases in GSH among patients with Hepatitis B and C, and found that these viruses are vulnerable to glutathione. In-vitro studies in Japan also showed that whey can stimulate the bone cell (osteoblasts) to produce more bone, hence increasing bone density and reducing the risk of osteoporosis. Lactalbumin from whey protein has been demonstrated to kill breast cancer cells in vitro (in a test-tube). Glutathione (from whey protein) lowers serum cholesterol by stimulating bile synthesis in the liver. In addition, glutathione is a powerful antioxidant that will prevent lipid peroxidation (a sign of free radical activity). Lipid peroxidation is implicated in arteriosclerosis (hardening of the arteries), stroke and coronary artery disease. Because neither bioactive whey protein nor glutathione is a drug, no disease treatment claims can be made on the basis of these studies. Top
Q. What is the theoretical mechanism of action of GLUTATHIONE in Cancer and Immune dysfunction?
A. Natural killer (Immune) cells may become glutathione-depleted over time, and immune response weakens. Bioactive whey protein raises glutathione levels and strengthens the immune system. The immuine system is the body's first line of defense against cancer, viruses, bacteria, etc. For those patients receiving traditional medical therapy for their cancer, bioactive whey protein supplies lactalbumin and has been clinically proven to raise glutathione levels. Glutathione and lactalbumin (a component of bioactive whey protein) have been associated with the strengthening of healthy cells and (paradoxically) the weakening of cancerous cells. In research conducted by C. Svanborg et al, lactalbumin was associated with apoptosis (or the programmed death) of breast cancer cells. Glutathione has been scientifically demonstrated to decrease cancerous cells' resistance to chemotherapeutic drugs, while protecting healthy cells. This would theoretically allow a patient to respond better to chemotherapy with less side effects. Because neither bioactive whey protein, lactalbumin, nor glutathione is a drug, no disease treatment claims can be made on the basis of these studies. Top
Q. What are the diseases or conditions that have been associated with low glutathione levels?
A. Most of the autoimmune and degenerative diseases of aging including: Acetaminophen poisoning, ADD, Addison's Disease, aging, AIDS, Alopecia Areata, ALS, Alzheimers' Disease, anemia (hemolytic), Ankylosing Spondylitis, Arteriosclerosis (hardening of the arteries), arthritis (rheumatoid), asthma, autism, autoimmune disease, Behcet's Disease, burns, cacexia, cancer, candida infection, cardiomyopathy (idiopathic), Chronic Fatigue Syndrome, colitis, coronary artery disease, cystic fibrosis, diabetes, Crohn's disease, eczema, emphysema, Epstein Barr Viral (EBV) syndrome, fibromyalgia, free radical overload, Goodpasture Syndrome, Graves' Disease, hepatic dysfunction (liver disease), hepatitis B, hepatitis C, hypercholesterolemia (high blood cholesterol), herpes, infections (viral, bacterial and fungal), inflammatory bowel disease (IBD), lupus, macular degeneration (diabetic macular degeneration), malnutrition, Meniere's disease, multiple sclerosis, Myasthenia Gravis, neurodegenerative diseases, nutritional disorders, Parkinson's disease, Pemphigus Vulgaris, Primary Biliary Cirrhosis, progeria, psoriasis, Rheumatic Fever, Sarcoidosis, scleroderma, shingles, stroke, surgery, toxic poisoning, trauma, vasculitis, vitiligo, and Wegener's Granulomatosis. No disease treatment claims can be made for glutathione on the basis of glutathione deficiency in these diseases. Top
Q. Has therapy to increase glutathione levels been effective in treating the diseases or conditions that have been associated with low glutathione levels?
A. See: Medline Search Page (replace the 5 Xs with the name of the disease you want to research). Please remember that because glutathione is not a prescription drug (except the injectable form) no disease treatment claims can be made for glutathione on the basis of glutathione deficiency in these diseases.
Q. Can a person who is lactose intolerant take Immunocal bioactive whey protein?
A. Yes, certain brands. Immunocal bioactive whey protein has less than 1% lactose which should not cause any ill effect even in the most severe case of lactose intolerance.
Q. Can a person who is intolerant of Monosodium Glutamate (MSG) take bioactive whey protein?
A. Yes, Immunocal bioactive whey protein has NO added MSG (trace amounts may occur naturally) which should not cause any ill effect in people with an MSG intolerance. Bioactive whey protein contains the following amount of glutamic acid by weight: 180 mg/gram. There is therefore 1.8 grams of glutamic acid in a 10 gram packet of bioactive whey protein. Every single protein on the earth contains glutamic acid, and glutamic acid is required for good health. Glutamic acid is an amino acid formed in the digestion of ALL proteins (including wheat gluten and meat). It is the only amino acid metabolized by the brain. Glutamic acid is necessary in human nutrition but can usually be manufactured by the body in adequate amounts. That means that our own body produces it. In certain disease states, deficient diet, malnutrition, and in certain metabolic abnormalities this amino acid becomes conditionally essential. Glutamic Acid's sodium salt, is monosodium glutamate, and ALL proteins may contain naturally occurring trace amounts of MSG. In summary, bioactive whey protein would not supply any more glutamic acid than a serving of steak or other similar protein. There is NO added MSG in bioactive whey protein, and its supplementation should not cause a medical problem in a persons sensitive to MSG. Top
Q. Are there any interactions known between supplements such as coenzyme Q-10, antioxidant vitamins, or herbs and bioactive whey protein?
A. No, there are no known potential or reported interactions between bioactive whey protein and nutritional supplements. In fact, bioactive whey protein increases glutathione levels, which helps to improve the action of antioxidant vitamins (which are less effective if your glutathione levels are impaired). For this reason, mega-doses of antioxidant vitamins (i.e. doses in excess of 10 times the RDA of these vitamins) are not required or recommended if you are supplementing with Immunocal bioactive whey protein. As we age, our glutathione levels fall precipitously like a down-hill ski-slope. Low levels of glutathione are associated with a host of degenerative diseases, and critically low levels of serum and tissue glutathione often predict that death is imminent. Supplementation with bioactive whey protein helps restore these precious glutathione levels, and helps the supplemental vitamins we are taking to work more effectively to maintain optimum health! Because neither bioactive whey protein, nor glutathione is a drug, no disease treatment claims can be made on the basis of these findings. Top
Q. Are there any interactions known between prescription medications and Immunocal bioactive whey protein?
A. No, there are no known interactions between bioactive whey protein and prescription drugs. Bioactive whey protein is composed of the same basic proteins which are found in human breast milk, and should be considered to be as safe to take as mothers' breast milk. Furthermore, bioactive whey protein is 90% protein, and is one of the best sources of highly-absorbable protein on the planet. Patients taking immunosuppressant drugs such as Cyclosporin® should consult their physician before taking bioactive whey protein. Top
Q. Are there any side effects associated with bioactive whey protein?
A. Bioactive whey protein increases serum and liver glutathione levels. When liver glutathione levels rise, the liver is able to more effectively detoxify the body (which is a beneficial function of bioactive whey protein). Some people (especially those who have been exposed to high levels of environmental toxins) may have a mild temporary reaction to these mobilized toxins as the liver is removing them from storage in body fat. Typically, reducing the dose of bioactive whey protein will allow these temporary side effects to quickly disappear. Bioactive whey protein is composed of the same basic proteins that are found in human breast milk, and has the same side effect profile as mothers' breast milk. Because bioactive whey protein is a milk protein, persons who are mildly allergic to milk proteins may experience minor gastric distress from bioactive whey protein. This gastric distress usually disappears if you reduce the dose. Persons with serious milk-protein allergies should not take bioactive whey protein Top
Q. Can you overdose bioactive whey protein? Is there any potential for toxicity if you take too much?
A. Your greatest risk is wasting your money if you take "too much" bioactive whey protein, since it is relatively expensive. Scientific data suggests that there is limited benefit from exceeding 3 grams per day (3 packets per day) of bioactive whey protein. Because our cells have an innate mechanism of "feed-back inhibition" with respect to the glutathione synthesis precursors (building blocks) provided by bioactive whey protein, there is no potential for making "too much glutathione" within the cell if large quantities of bioactive whey protein are consumed. Bioactive whey protein supplementation will result in establishment of normal glutathione levels, (NOT excessive glutathione levels) within the cell. Excess bioactive whey protein would be metabolized as protein (whey protein is an excellent source of protein, containing 90% protein by dry weight). Top
Q. Because Immunocal bioactive whey protein is 90% protein, is it contraindicated in patients on renal dialysis who must limit protein intake?
A. No, bioactive whey protein is not contraindicated in these patients. Although we suggest that you consult your personal physician with medical questions such as these, there is no reason to believe that bioactive whey protein would be harmful in these patients. Bioactive whey protein is one of the most easily digested and most easily absorbed forms of protein in the diet. Its Protein Efficiency Ratio (PER: a mark of the quality of a protein) is extremely high, and in conditions such as renal failure where protein intake must be limited, it is most prudent to consume the highest quality proteins such as whey proteins and egg white proteins, versus lower quality proteins that produce more problematic metabolic waste by-products and residues.
Q. Is bioactive whey protein contraindicated in Celiac Sprue disease?
A. No. These patients are usually instructed not ingest wheat or gluten. There is no wheat, or gluten found naturally in bioactive whey protein. Furthermore, at least one brand of bioactive whey protein (Immunocal) is lactose-free. There is no reason to believe that that Immunocal bioactive whey protein would be detrimental in patients with Celiac Sprue. Top
Q. Who should not take the product?
A. People with an allergy specifically to milk protein, (which is very rare). NOTE: Please understand that lactose intolerance is NOT a milk allergy. Also, anyone who has had an organ transplant and is receiving immunosuppressant therapy should not take bioactive whey protein unless instructed to do so by his or her physician or another health care professional. The immune system needs to be suppressed in order to prevent organ rejection, and bioactive whey protein may counteract immunosuppressant medicines such as cyclosporin®.
Q. What are some of the critical ingredients in a daily amount of Immunocal bioactive whey protein (1 pouch)?
A. 9 grams or 90% Protein, 0 Fat, less than 0% Lactose, 60 mg of Calcium, 4 micrograms of Selenium, 30 Mg of Potassium, 0.05 mg of Iron, and approximately 40 Calories. Top
Q. What is the recommended dose for taking Immunocal bioactive whey protein?
A. Check with your physician or health care professional. If you do not have a documented glutathione deficiency and are taking bioactive whey protein to maintain good health, one pack per day is not unreasonable. Generally, most studies conducted using bioactive whey protein in patients with glutathione deficiencies used at least 20 grams per day (2 pouches), and some studies showed increased effectiveness using up to 30 grams (3 pouches) per day. Most people use 2 boxes per month (this provides 2 pouches, or 20 grams per day per month).
Q. What is the recommended intake of protein for an average adult per day? A. 50-60 grams of protein. Three packets of bioactive whey protein would provide 50% of this recommended daily intake. Top
Q. What is the difference in taking Immunocal bioactive whey protein as opposed to taking antioxidants?
A. Vitamin E and C are important antioxidants, and you should consider these important supplements in your diet. Bioactive whey protein is not an antioxidant per se, but provides the building blocks for the synthesis of glutathione, which is THE principle intra-cellular antioxidant. Glutathione is the most potent cellular antioxidant known to man, and is hundreds of times more potent than vitamin C or vitamin E. For this reason, glutathione has been called the "Super Antioxidant". By raising the glutathione level within our bodies we provide for the optimum functioning of other lesser antioxidants such as vitamins C and E. More importantly, glutathione serves as a detoxifying agent for multiple toxins that we encounter on a daily basis through the environment and medications we are exposed to. Glutathione has been demonstrated to act as an effective protectant against ultraviolet radiation, which is important in view of the continued loss of the ozone layer. Top
Q. How much does Immunocal bioactive whey protein cost?
A. Immunocal is available from the manufacturer or manufacturer's representatives for as little as $59.40/box.
Q. Is there a test to determine if my glutathione levels are low?
A. Yes. We know of a licensed laboratory that charges only $40 for this test. DISCLAIMER: We are NOT associated with this laboratory, nor do we receive ANY reimbursement from recommending their services.
Q. Is Immunocal bioactive whey protein listed in the Physicians Desk Reference (PDR)?
A. Yes. Immunocal bioactive whey protein produced from organic USA cow's milk and manufactured and processed in the United States is the ONLY nutritional product sold by direct sales to be listed in the prestigious PDR, which is also frequently called the "physician's bible", and is owned and consulted by virtually every physician in the USA and world-wide! Physicians have relied on the PDR for up-to-date information on prescription drugs for over 50 years. The PDR is considered the standard prescription drug reference and is found in virtually every physician's office. Although this brand of bioactive whey protein does NOT require a prescription, it's inclusion in the PDR is a result of recognition by the medical community, of the extensive clinical data supporting it's effectiveness, and as a result of it's recognition by Medicare and Medicaid as reimbursable. The publisher of the PDR, Medical Economics, also produces a smaller companion volume for non-prescription drugs and herbal medicines. This volume may contain references to other bioactive whey proteins and other nutritional supplements. Top
Q. What is the best way to mix Immunocal?
A. Because bioactive whey protein is a very fine and delicate powder, the manufacturer recommends mixing it with water or any juice or liquid that is not above lukewarm (less than 110 degrees F, and NEVER above 120 degrees F) temperature. First, mix the packet with approx. 1 tablespoon of the liquid you have chosen to form a paste. Second, now pour the liquid to fill your glass. Allow it to sit for a few minutes, stir, and enjoy. It can also be mixed in applesauce, yogurt, or sprinkled over cereal without any particular mixing procedure. The product CANNOT be mixed in a blender (mechanical mixing damages the milk proteins). You must stir by hand, or you can purchase an inexpensive "vortex-mixer".
Q. How can I order Immunocal?
A. The most economical way is to select "ImmunoDirect monthly autoship program". You will get the lowest discount and can cancel at any time--even the following week--without penalty or obligation. Most folks chose to continue to receive Immunocal on a monthly basis, conveniently shipped to their home the same time each month. Top
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"Antioxidants are well documented and known to possess vital roles in health maintenance and disease prevention. Glutathione is your cell's own major antioxidant. Maintaining elevated glutathione levels aids the body's natural antioxidant function." - Biochemical Pharmacology 47: 2113-2123 1994
You may or may not have heard of glutathione, even though over tens of thousands of medical articles have highlighted its importance. Optimizing glutathione levels will shortly join the list of factors known by everyone to have an impact on our health and well-being. Learn more about Glutathione, the Most Powerful Antioxidant, Plays a Critical Role in the Cellular Detoxification Processes
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Utilization of GSH. Research has shown that individuals who have low levels of glutathione are susceptible to chronic illness. Research shows that GSH levels (glutathione) decline by 8% to 12% per decade, beginning at the age of 20. Levels of glutathione are further reduced by continual stress upon the immune system such as illness, infection, and environmental toxins. As we now know, a lowered immune system can bring about illness and disease. This is a ferocious cycle. While you need glutathione for a productive immune system, a weakened immune system hampers the production of glutathione. Supplements Containing Glutathione Alone Will NOT Increase The Body’s GSH Levels. It is pointless to purchase supplements that merely contain glutathione, because the digestive system breaks down ingested glutathione and it will not be absorbed into your system. On the other hand, Immunocal provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. Immunocal also aids in liver support by destroying environmental poisons helping the liver to function as the main production site and storehouse for glutathione.
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Glutathione has three important functions: It serves as an Antioxidant, an Immune system enhancer and a Detoxifier.
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Clinical results documented an average increase of 292% in intercellular Glutathione levels for persons taking Immunocal for 60 days. Amazingly, the same report showed an average increase of 46% of DHEA and 40.8% for IGF-1, both markers related to levels of human growth hormone, the indicators of true biological age. Furthermore, TNF improved 37%. TNF (Tumor Necrosis Factor alpha) is one of the three most significant markers of cellular inflammation.In an unrelated study, researchers recently discovered that Centenarians between the ages of 100 to 105 years of age have Glutathione levels similar to 30-50 year old well, physically fit, healthy individuals. Does increased Glutathione levels in your body help you live longer? Given the choice, I think I would rather have an ample supply of Glutathione in my body than be Glutathione deficient.
The benefits of taking Immunocal include the following:
Improved energy.
Better quality of sleep.
Improved mood.
Improved mental focus.
Decreased aches and painGlutathione for Health and Energy
Glutathione is the most powerful antioxidant and antitoxin in your body. Increasing Glutathione levels will naturally increase your energy, detoxify your body and strengthen your immune system. Glutathione is a protein produced naturally in our cells. Unfortunately, as we grow older our body produces less and less of this vital health compound. It is our major defense system against illness and aging.Our Glutathione levels indicate our state of health and can predict longevity. Glutathione is used by every cell in our body. It doesn't matter if it is a cell in your big toe, a heart muscle cell, or a brain cell. All cells must have ample quantities of Glutathione to function normally and stay healthy and generate energy.
Glutathione for Wellness and Living Longer
Glutathione improves mental functions, improves concentration, increases energy, promotes increased levels of exercise, helps chronic pain disorders, lowers blood pressure, improves heart and lung functions, and helps control the effects of diabetes. Increasing age and and other factors reduce the body's production and utilization of Glutathione. Research has shown that individuals who have low levels of Glutathione are susceptible to chronic illness and a myriad of medical problems.
Clinical data indicates our Glutathione levels decline by 8% to 12% per decade, begriming at the age of 20. Levels of Glutathione are further reduced by continual stress upon the immune system such as illness, infection, and environmental toxins and pollutants. A lower immune system results in higher incidents of illness and disease. This condition is a ferocious cycle. While you need Gluathione for a productive immune system a weakened immune system hampers the production of Glutathione. Supplements that only contain Glutathione will not increase the body's Glutathione. It is useless to purchase supplements that merely consists of only Glutathione, because the digestive process destroys ingested Glutathione.
Immunocal provides the proper nutrients (precrusors) needed to get through the stomach and into the blood to generate Glutathione. Immunocal also aids in liver support by destroying enviromental poisons and pollutants thus helping the liver to function as the main production site and storehouse for Glutahione.
Immunocal, A Natural Source of the Glutathione GSH Building Block
We eat over-processed food that is devoid of nutrients and laced with pesticides and herbicides. We drink water polluted with industrial toxins and heavy metals. We breathe air polluted with toxic fumes and then we expect our body to function normally. Most of us live in an environmental nightmare—a toxic chemical soup. Our body tries to cope the best it can; however, the low quality food we eat, and the polluted air and water we consume endangers our health and longevity.
The human body was not built to process pollutants and food crammed with chemical preservatives and stripped of vital nutrients. Emotional and medical stress, and environmental toxins create free radicals as our body tries to fight these health hazards. These hazards constantly bombard our natural defenses and can eventually deplete our internal supply of Glutathione. The end result is low energy, disease, and medical impairments ranging from heart disease, diabetes, cancer and even premature death.
Decreases in brain Glutathione levels induced by Sleep Deprivation
Department of Psychobiology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil.
Recent findings from this laboratory revealed that sleep deprivation reduces total glutathione GSH levels in hypothalamus, suggesting an increased vulnerability to oxidative damage. These results confirm that sleep deprivation reduces hypothalamic GSH…
The objective, therefore, was to study glutathione content in the liver, heart, and lung, because glutathione is considered a major free radical scavenger that reflects the degree to which a tissue has been oxidatively challenged. We also investigated major enzymatic antioxidants, including catalase and glutathione peroxidase, as well as indexes of glutathione recycling. Catalase activity and glutathione content, which normally are tightly regulated, were both decreased in liver by 23–36% by 5 and 10 days of sleep deprivation.
Such levels are associated with impaired health in other animal models of oxidative stress-associated disease. The decreases were accompanied by markers of generalized cell injury and absence of responses by the other enzymatic antioxidants under study. Enzymatic activities in the heart indicated an increased rate of oxidative pentose phosphate pathway activity during sleep deprivation. Recovery sleep normalized antioxidant content in liver and enhanced enzymatic antioxidant activities in both the liver and the heart. The present results link uncompensated oxidative stress to health effects induced by sleep deprivation and provide evidence that restoration of antioxidant balance is a property of recovery sleep.
Food Sources That Boost Glutathione Naturally
By Priya Shah
Copyright © 2004 Priya Shah
Glutathione, the body's master antioxidant and detoxifier, is one of the 14 "Superfoods" listed in SuperFoods Rx : Fourteen Foods That Will Change Your Life, co-authored by Dr Steven Pratt. Glutathione levels cannot be increased to a clinically beneficial extent by orally ingesting a single dose of glutathione. (1) This is because glutathione is manufactured inside the cell, from its precursor amino acids, glycine, glutamate and cystine.
Hence food sources or supplements that increase glutathione must either provide the precursors of glutathione, or enhance its production by some other means. The manufacture of glutathione in cells is limited by the levels of its sulphur-containing precursor amino acid, cysteine.
Cysteine - as a free amino acid - is potentially toxic and is spontaneously catabolized or destroyed in the gastrointestinal tract and blood plasma. However, when it is present as a cysteine-cysteine dipeptide, called cystine, it is more stable than cysteine. Consuming foods rich in sulphur-containing amino acids can help boost glutathione levels. Here are some food sources and dietary supplements that help boost glutathione levels naturally.
1. N-Acetyl-Cysteine (NAC) It is derived from the amino acid L-Cysteine, and acts as a precursor of glutathione. NAC is quickly metabolized into glutathione once it enters the body. It has been proven in numerous scientific studies and clinical trials, to boost intracellular production of glutathione, and is approved by the FDA for treatment of accetaminophen overdose. Because of glutathione's mucolytic action, NAC (brand name Mucomyst) is commonly used in the treatment of lung diseases like cystic fibrosis, bronchitis and asthma.
2. Milk Thistle, Silymarin Milk thistle is a powerful antioxidant and supports the liver by preventing the depletion of glutathione. Silymarin is the active compound of milk thistle. It is a natural liver detoxifier and protects the liver from many industrial toxins such as carbon tetrachloride, and more common agents like alcohol.
3. Alpha Lipoic Acid Made naturally in body cells as a by-product of energy release, ALA increases the levels of intra-cellular glutathione, and is a natural antioxidant with free radical scavenging abilities. It has the ability to regenerate oxidized antioxidants like Vitamin C and E and helps to make them more potent. ALA is also known for its ability to enhance glucose uptake and may help prevent the cellular damage accompanying the complications of diabetes. It also has a protective effect in the brain.
4. Natural Foods That Boost Glutathione Levels Asparagus is a leading source of glutathione. Foods like broccoli (2), avocado and spinach are also known to boost glutathione levels. Raw eggs, garlic and fresh unprocessed meats contain high levels of sulphur-containing amino acids and help to maintain optimal glutathione levels.
5. Undenatured Whey Protein Isolate Whey protein contains proteins like alpha-lactalbumin which is is rich in sulphur-containing amino acids. Heating or pasteurization destroys the delicate disulphide bonds that give these proteins their bioactivity. Undenatured whey protein is a non-heated product that preserves bioactive amino acids like cystine. It has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.
6. Curcumin (Turmeric) Treatment of brain cells called astrocytes, with the Indian curry spice, curcumin (turmeric) has been found to increase expression of the glutathione S-transferase and protect neurons exposed to oxidant stress. (3)
7. Balloon Flower Root Changkil saponins (CKS) isolated from the roots of the Chinese herbal medicine, Platycodon grandiflorum A. DC (Campanulaceae), commonly called Balloon Flower Root or Jie Geng, have been found to increase intracellular glutathione GSH content and significantly reduce oxidative injury to liver cells, minimise cell death and lipid peroxidation. (4)
8. Selenium Selenium is a co-factor for the enzyme glutathione peroxidase. Selenium supplements have become popular because some studies suggest they may play a role in decreasing the risk of certain cancers, and in how the immune system and the thyroid gland function. However, too much selenium can cause some toxic effects including gastrointestinal upset, brittle nails, hair loss and mild nerve damage. Disclaimer: The information here is not provided by medical professionals and is not intended as a substitute for medical advice. Nutritional supplements, while usually benign, can produce adverse reactions in some people. As with prescribed drugs, long-term effects from supplements are often unknown. Pregnant women and children should not take supplements except after consultation with their healthcare provider. Never exceed the recommended dosage on the container. If you observe adverse effects stop taking the supplement immediately and contact your healthcare provider.
References:
1. The systemic availability of oral glutathione Witschi A, Reddy S, Stofer B, Lauterburg BH. [Eur J Clin Pharmacol. 1992;43(6):667-9.]
2. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system Wu L, Ashraf MH, Facci M, Wang R, Paterson PG, Ferrie A, Juurlink BH. [Proc Natl Acad Sci U S A. 2004 May 4;101(18):7094-9. Epub 2004 Apr 21.]
3. Can Curry Protect Against Alzheimer's? American Physiological Society (APS) Press release; 16-Apr-2004
4. Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity
Lee KJ, Choi CY, Chung YC, Kim YS, Ryu SY, Roh SH, Jeong HG. [Toxicol Lett. 2004 Mar 7;147(3):271-82.] This article was first published in the July 2004 issue of The Glutathione Report, a newsletter featuring regular updates on the health benefits of glutathione. Get a Free report on Glutathione in Health and Disease Article Source: http://EzineArticles.com/?expert=Priya_Shah
IMMUNOCAL REFERENCES1. Bounous G, Stevenson MM, Kongshavn PAL. Influence of dietary lactalbumin hydrolysate on the immune system of mice
and resistance to Salmonellosis. J Infect Dis 144: 281, 1981.
2. Bounous G, Letourneau L, Kongshavn PAL. Influence of dietary protein type on the immune system of mice. J Nutr 113:
1415-21, 1983.
3. Bounous G, Kongshavn PAL. Influence of protein type in nutritionally adequate diets on the development of immunity. In:
Absorption and Utilisation of Amino Acids. M. Friedman (Ed.). Boca Raton, Florida: CRC Press, vol. 2, 219-32, 1989.
4. Bounous G., Batist G, Gold P. Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin Invest
Med 12: 154-61, 1989.
5. Bounous G, Shenouda N, Kongshavn PAL, Osmond DG. Mechanism of altered B-cell response induced by changes in
dietary protein type in mice. J Nutr 115: 1409-17, 1985.
6. Bounous G, Papenburg R, Kongshavn PAL, Gold P., Fleiszer D. Dietary whey protein inhibits the development of
dimethylhydrazine-induced malignancy. Clin Invest Med 11: 213-7, 1988.
7. Papenburg R, Bounous G, Fleiszer D, Gold P. Dietary milk proteins inhibit the development of dimethylhydrazine-induced
malignancy. Tumor Biol 11: 129-136, 1990.
8. Bounous G., Batist G., Gold P. Whey proteins in cancer prevention. Cancer letters 57, 91-94, 1991.
9. Bounous G, Baruchel S, Falutz J, Gold P. Whey proteins as a food supplement in HIV seropositive individuals. Clin Invest
Med 16: 204-209, 1993.
10. Baruchel S, Viau G, Olivier R, Bounous G, Wainberg M.A. – Nutriceutical Modulation of Glutathione with a Humanised
Native Milk Serum Protein Isolate, Immunocal®.
11. Application in AIDS and Cancer. In: Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases. Ed. L.
Montagnier, Olivier R., Pasquier C. Publ Dekker M., New York, 447-461, 1998.
12. Lands L, Grey VL, Smountas AA. The Effect of Supplementation with a Cysteine Donor on Muscular Performance. Journal
of Applied Physiology Vol. 87: 1381-1385, 1999.
13. Lotian B, Grey V, Kimof RJ, Lands L. Treatment of Obstructive Airway Disease with a Cysteine Donor Protein Supplement:
A Case Report. Chest; 117: 914-916, 2000.
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